PPARA and hypertriglyceridemia: Synthetic ligands for PPARα are fibrates used in treating hypertriglyceridemia (the effectiveness of the use of fibrates is rather low for other PPAR isoforms); PPARβ/δ synthetic ligands are GW501516, GW0742, and L-165041; PPARγ synthetic ligands are thiazolidinediones widely used for the treatment of diabetes and having pronounced anti-inflammatory properties [33, 37, 38, 46, 89, 145].