In addition, CXCL8, also known as a neutrophil chemotactic factor, is a typical chemokine produced in the progression of gout, which responsible not only for inducing neutrophils to migrate toward the gout lesion, but also for stimulating the cells to release neutrophil extracellular traps (NETs) through the CXCL8/CXCR2 axis. Here, CXCR2 is linked to gout.