AFP and hepatocellular carcinoma: Recently, we (15) and others (16) identified the human alpha fetoprotein (AFP)- specific TCR genes from mouse and human and showed that human T cells genetically modified with the AFP-specific TCRs could effectively kill HCC tumor cells and eliminated HCC xenografts in immune compromised NSG mice (15), demonstrating the potential of the TCR-Ts for HCC immunotherapy.