The cluster of pathogenic variants defining β‐thalassemia in Kilifi, observed through this study, is dominated by two β0‐thalassemia variants, CD22 (GAA→TAA; 66.3%) and initiation codon (ATG→ACG; 24.1%), while the remaining cases were explained by one additional β0‐(IVS1‐3ʹ end del 25bp) and a single β+‐thalassemia variant [IVS‐I‐110 (G→A)]. The gene discussed is CD22; the disease is thalassemia.