Seven children out of the group of 25 children (28%) with 1 of the other gene mutations developed late onset feeding problems: 1 child with a SOS1 mutation due to gastroesophageal reflux disease, 1 child with a SHOC2 mutation developed feeding problems mainly due to a 3MCC deficiency, 1 child with a SHOC2 mutation due to malabsorption, 1 child with SOS2 mutation due to the Dubin–Johnson syndrome, 1 child with CBL mutation due to juvenile myelomonocytic leukaemia, 1 child with CBL mutation due to cow’s milk allergy and 1 child with CBL mutation due to delayed gastric emptying. The gene discussed is SHOC2; the disease is gastroesophageal reflux disease.