There was no difference in the prevalence of the documented presumed or proven cause between the different groups (prevalence of gastroesophageal reflux disease: PTPN11 vs SOS1: p = 1.00; PTPN11 vs other gene mutations: p = 0.08, SOS1 vs other gene mutations: p = 1.00). This evidence concerns the gene PTPN11 and gastroesophageal reflux disease.