In two studies, the degree of hyperglycemia correlated with an increased loss of GLUT2-expressing β-cells, a decline in GLUT2 mRNA and protein along with a reduced β-cell mass resulting in a diminished uptake of 3-OMG and impaired GSIS in pancreases isolated from ZDF rats [58, 104]. Here, SLC2A2 is linked to Hyperglycemia.