Five years later, Bonner and colleagues demonstrated SGLT2 mRNA and protein expression in human glucagon-secreting α-cells, being differentially regulated under conditions of altered glucose homeostasis with enriched SGLT2 mRNA levels in obese, glucose intolerant (GI) and T2D islets compared to lean controls [9]. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.