MGMT and central nervous system cancer: Possible treatment strategies for radiotherapy of glioma patients including concomitant and adjuvant chemotherapy are predominantly based on the WHO grade and, more importantly, on molecular characteristics of the tumor [3], namely the IDH genotype [4], the 1p/19q status [5–7], and the O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status [8–10].