SERPINE1 and cancer: These results are generally in line with literature, where high PAI-1 tissue levels were associated with unfavorable prognostic factors in various cancer types (Brungs et al. 2017; Fredstorp-Lidebring et al. 1990; Tecimer et al. 2001; Steiner et al. 2008; Kohler et al. 1997; Lampelj et al. 2015).