PLAU and neoplasm: Previous studies showed the prognostic value of tumor tissue levels of uPA, tPA, PAI-1 and -2, and VEGF in predicting metastases, recurrence, therapy response, and survival of patients with various tumors types, such as breast-, lung-, and cervical cancer (Poon et al. 2001; Duffy and Duggan 2004; Witte et al. 1999a; Shaarawy and El-Sharkawy 2001; Saarelainen et al. 2014; Zusterzeel et al. 2009; Harbeck et al. 1990).