Together, these data suggest that TOX, and potentially TIM-3, CTLA-4, VISTA, TIGIT, KLRG1, TOX2, SIRT1, Ki-67, and Helios mRNA levels in CRC tumor tissues increase in advanced disease stages (Table 2), suggesting their possible roles in CRC progression. The gene discussed is IKZF2; the disease is colorectal carcinoma.