BRCA1 and cancer: Most previous studies have reported on predictors of cancer-related distress in women from single institutions and have included women with cancer.1–5 Both cancer and genetic status have been shown to raise cancer-related distress.13 We chose to focus on unaffected women with a positive BRCA1 or BRCA2 genetic test result to determine if there were modifiable predictors that could be the targets of interventions to reduce cancer-related distress in this subgroup.