In the presence of stimuli, e.g., cell/cell contact, and the subsequent phosphorylation and activation of downstream tumor-suppressive mammalian sterile 20-like 1/2 (Mst1/2), Salvador 1, large tumor suppressor kinase 1/2 (Lats1/2), and Mps one binder kinase activator-like 1A (Mob1) complexes, YAP and TAZ transcription coactivators are sequestered in the cytoplasm, leading to the contact inhibition-mediated suppressed cell growth. Here, LATS1 is linked to neoplasm.