For example, TAZ and Nedd4 WW domains interact with the WBP2 PY2 motif [12, 64], ITCH WW domains 1 and 3 interact with WBP2 PY2 and PY3 motifs to regulate cancer growth [13], while WWOX and YAP WW domains interact with PY3 [12, 65] (Fig. 4). The gene discussed is ITCH; the disease is cancer.