WBP2 and cancer: It is further recommended that expression of WBP2 be assessed by IHC, immunofluorescence, or immunocytochemistry techniques as the subcellular localization of WBP2, e.g., nuclear WBP2, can be a diagnostic feature since the oncogenic phosphomimetic WBP2 mutant resides in the nucleus and nuclear staining of WBP2 has been largely observed in cancer but not normal tissues [13].