Consistent with our observation that WBP2 induced the activation of Akt protein in breast cancer [11], Chen et al. reported that WBP2 interacted with α-enolase (ENO1) and homer protein homolog 3 (Homer3) and that the ENO1-PI3K/Akt signaling axis drove the proliferation and migration of glioma cells [17]. Here, HOMER3 is linked to central nervous system cancer.