The importance of nuclear WBP2 to breast cancer progression was demonstrated when our lab showed that the WBP2-phosphomimic mutant (Y192–231E), which translocates more effectively into the nucleus, conferred oncogenic properties to non-cancer mammary epithelial cells and aggression to low-grade cancer cells compared with wild-type WBP2 or its phospho-defective mutant (Y192–231F) in vitro and in xenograft models [11]. This evidence concerns the gene WBP2 and cancer.