Importantly, IRF3-deficient mice did not demonstrate an increase in survival upon treatment with FMT (Fig. 3d) and FMT-treated IRF3-deficient mice had significantly higher PC burden in peripheral sites when compared with FMT-treated IRF3-sufficient littermates (Fig. 3e) indicating that FMT required intact IRF3 to clear the PC and rescue mice from pathogen-induced lethal sepsis. This evidence concerns the gene IRF3 and Sepsis.