RCC2 and renal cell carcinoma: Western blot results demonstrated that phosphorylation of AKT (at both Ser-473 and Thr-308) and S6K1 (at Ser-389) were inhibited by SC66 (3 μM, 2 h) in both 786-O and primary RCC cells (“RCC1/RCC2”) (Fig. 3a).