The results showed that the expression levels of seven tRNA-modifying genes (FTSJ1, ADAT1, U13, RNMTL1, TRDMT1, METTL14, and TRMT1L) in NSCLC tumor tissues were significantly lower than that in normal tissues (all P values < 0.05) (Fig. 2a–j). Here, TRDMT1 is linked to neoplasm.