INS and obesity due to melanocortin 4 receptor deficiency: Protein exhibits the strongest genetic correlations with poor health outcomes, including obesity (rg = 0.35, SE = 0.04), type 2 diabetes (rg = 0.45, SE = 0.06), fasting insulin (rg = 0.41, SE = 0.08), and coronary artery disease (rg = 0.16, SE = 0.04), as well as BMI (rg = 0.40, SE = 0.04) (Fig. 3, Supplementary Table 10.2).