Although previous studies demonstrated a role of TAGLN as a tumor suppressor and its inhibition is an early event in tumor transformation and development24,25,41, recent clinical and functional proteomic evidence showed its association with enhanced cell invasion, cell survival, activation of epithelial-to-mesenchymal transition (EMT) and resistance to anoikis (apoptosis induced by cell detachment) during the distant metastasis stage42. This evidence concerns the gene TAGLN and neoplasm.