Molecular profiling comparing TAGLNhigh and TAGLNlow colon cancer patients’ specimens shedding some light on the activation of a number of mechanistic networks, including SMARCA4, TGFβ1, and P38 MAPK while remarkable enrichment in a number of functional categories associated with cellular movement and angiogenesis was most prominent in TAGLNhigh, suggesting biological relevance to our in vitro findings in patients with colorectal cancer. The gene discussed is TGFB1; the disease is colorectal cancer.