Concerning the specific function of circMAST1 in cell proliferation, we found that cyclin A, cyclin E, CDK1, and CDK2 expression levels were changed owing to circMAST1 silencing Our data also showed that circMAST1 silencing inhibited HCC cell migration and invasion, which are important determinants of tumor metastasis35. This evidence concerns the gene CDK2 and neoplasm.