TNKS and colorectal carcinoma: Furthermore, rescue experiment revealed that circ5615 significantly attenuated the suppression of miR-149-5p on TNKS and knockdown of TNKS significantly attenuated the effects of circ5615 on Wnt/β-catenin signaling (Fig. 6g), suggesting that circ5615 promoted CRC progression via a miR-149-5p-TNKS-dependent mechanism.