First, we noted that active MM samples were significantly more sensitive than smoldering MM (SMM) samples to all studied HDAC inhibitors, selinexor, the signal transduction inhibitors targeting ALK (ceritinib), MAPK (cobimetinib, trametinib), CDKs (dinaciclib), RTKs (sunitinib, ponatinib), and AKT (afuresertib). The gene discussed is HDAC9; the disease is Miyoshi myopathy.