The broad neurologic phenotypes of RTT overlap with multiple other neurologic disorders, both neurodevelopmental (e.g., ASD, some forms of cerebral palsy, and epilepsy) and acquired (e.g., traumatic brain injury), raising interesting questions regarding converging underlying mechanisms and possible involvement of NF-κB signaling, either causal or potentially permissive for enhanced recovery. Here, NFKB1 is linked to epilepsy.