Tau aggregation and neurotoxicity act as the final common pathway in multiple neurodegenerative diseases, including Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTLD), chronic traumatic encephalopathy (CTE) and primary age-related tauopathy (PART; Morris et al., 2011; Crary et al., 2014). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.