PRNP and Cognitive impairment: Likewise, it has been reported that α-syn oligomeric species interact with PrPC through mGluR5, activating SFK kinases and, subsequently, NMDAR2B to induce neuronal dysfunction and cognitive deficits in Thy1-aSyn mice and also that the toxic effects induced by α-syn oligomers may be prevented using antibody-mediated inactivation of PrPC (Ferreira et al., 2017).