EVI5 and non-small cell lung carcinoma: To address this question, a dual-luciferase reporter assay was performed, and it showed that miR-486-5p significantly inhibited luciferase activity in cells transfected with the wild-type EVI5 3′-UTR, Moreover, overexpression of miR-486-5p prevented EVI5-induced cell proliferation, migration and invasion in NSCLC cells, which further confirms the tumor-promoting function of EVI5 and provides more clues to the regulation network of EVI5.