FBXO5 and non-small cell lung carcinoma: Combined with the previous findings, we examined complexes of EVI5 and Emi1 using co-immunoprecipitation, the result showed that EVI5 overexpression in NSCLC indeed significantly increased expression of Emi1, and EVI5 knockout in NSCLC indeed significantly decreased expression of Emi1 (Fig. 4d).