SMAD3 and neoplasm: To clarify the mechanism underlying EVI5-mediated tumor metastasis, we analyzed the molecular expression of TGF-β receptor II, TGF-β receptor I, p-Smad3, Snail, Vimentin, MMP2 and N-Cadherin levels were significantly decreased and E-Cadherin was significantly increased in EVI5-knockdown cells (Fig. 5b).