Compared with the colonic polyps group with normal glucose tolerance, the BMI, WHR, FPG, 2hPG, TGs, HOMA-IR, visfatin, leptin, and resistin levels were significantly higher in the colonic polyps group with prediabetes (P = 0.026 for BMI; P = 0.033 for WHR; P = 0.001 for FPG; P < 0.001 for 2hPG; P = 0.041 for TG; P = 0.046 for HOMA-IR; P = 0.011 for visfatin; P = 0.042 for leptin; P = 0.039 for resistin, respectively), but the adiponectin level was significantly lower [(5.6 ± 3.7 vs 9.8 ± 4.8) mg/L, P = 0.024). This evidence concerns the gene LEP and prediabetes syndrome.