To identify the risk factors for colonic polyps in prediabetes subjects, the multivariate unconditional logistic regression analysis was performed after adjustment for sex, age, BMI, WHR, 2hPG, TGs, adiponectin, visfatin, leptin, resistin, current smoking, alcohol drinking, family history of colon cancer to determine the risk factors for colonic polyps in prediabetes subjects. This evidence concerns the gene LEP and colon inflammatory polyp.