CAPNS1 and myocardial infarction: Notably, according to experimental findings of a myocardial infarction mouse model with cardiomyocyte-specific deletion of Capn4, Capn4 knock-out correlated with restoration of IκB protein and inhibition of NF-κB activation, resulting in the inhibition of proinflammatory cytokine expression and inflammatory cell infiltration in the Capn4 knock-out heart after myocardial infarction [46].