FLT3 and acute myeloid leukemia: To determine whether pharmacologic inhibition of ULK1 affects autophagy pathway in FLT3-ITD AML cells, we evaluated the effects of MRT 68921 on ULK1-downstream molecules p-ATG13, LC3 conversion, and p62 in MV4–11 and U937 cells compared with those in the DMSO control.