We demonstrated here for the first time that two ULK1 inhibitors, MRT 68921 and SBI-0206965, induced caspase-dependent apoptosis preferentially in FLT3-ITD-mutated leukemia cell lines and primary leukemic blasts obtained from FLT3-ITD AML patients, while sparing normal CD34 (+) cells. Here, ULK1 is linked to acute myeloid leukemia.