As shown in Supplementary Table S1 (Additional file 2) and Fig. 2b and c, the extent of MRT 68921- or SBI-0206965-induced apoptosis was significantly higher in the primary FLT3-ITD blasts than in the leukemia cells obtained from FLT3-WT AML cases (MRT 68921; p = 0.0001, SBI-0206965; p < 0.0001). The gene discussed is FLT3; the disease is acute myeloid leukemia.