To this end, we comprehensively analyzed normal myeloid cells with inducible PML-RARα, and patient-derived APL cells with native PML-RARα, to determine the roles of PML-RARα in 3D genome organization and transcription regulation, using integrative approaches including ChIA-PET for chromatin interactions, ChIP-seq for epigenomic states, and RNA-seq for transcriptional outputs. This evidence concerns the gene PML and acute promyelocytic leukemia.