PML and acute promyelocytic leukemia: Gene Ontology analysis to this set of genes showed that they are significantly enriched in biological processes associated with hemopoiesis, immune processes, myeloid cell activation, and differentiation (Fig. 3c), further validating that at least part of the functions of PML-RARα is to act via repressing the transcription of genes involved in myeloid cell differentiation during APL pathogenesis.