In this study, we comprehensively mapped the 3D genome organizations and epigenomic features of normal myeloid cells and APL cells using integrative approaches including ChIA-PET for chromatin topology, ChIP-seq for epigenomic state, and RNA-seq for transcriptional output, to analyze the effects of the oncogenic fusion protein PML-RARα on the myeloid genomes. The gene discussed is PML; the disease is acute promyelocytic leukemia.