CCND1 and melanoma: The four-color FISH probes for 6p25 (RREB1-Ras responsive element-binding protein-1), 6q23 (MYB-myeloblastosis), 11q13 (CCND1,cyclin-D1 or chromosome 11q), and CEP6 (a centromeric reference point on chromosome 6) distinguished melanoma and benign melanocytic lesions according to variation in copy number of the genes, usually gain.