The second study by Hugdahl and colleagues [23] has shown that BRAF V600E expression in primary melanoma is associated with reduced survival, however BRAF expression was not assessed in relation to BRAF inhibitor treatment, additionally the samples recruited in this study were primary melanoma; the pathophysiological processes may differ between primary tumors and tumor metastases and the conclusions in studies focused on primary tumors may not necessarily apply to studies focused on tumor metastases. The gene discussed is BRAF; the disease is neoplasm.