The role for MIR21 in malignancy was first reported by Chan et al. [25], and is now known to be ubiquitously expressed in cancer cells [26] as MIR21 targets and inhibits pro-apoptotic proteins, programmed cell death 4 (PDCD4) and phosphatase and tensin homolog (PTEN) [27, 28]. This evidence concerns the gene PDCD4 and cancer.