Considering that elevated estrogen during pregnancy could also potentially contribute to the activation of cAMP pathway through reacting on corresponding G-protein-coupled receptor (GPCR), immunohistochemistry (IHC) was performed on the adrenal adenoma tissue of our case to detect the expression of G protein-coupled receptor-1 (GPER-1), as well as LHCGR and melanocortin 2 receptor (MC2R). The gene discussed is MC2R; the disease is adrenal cortex adenoma.