It has been demonstrated that human ASC-exosomes can ameliorate AD in two distinct mouse models via reducing pathological symptoms and expression of multiple cytokines such as IL-4, IL-5, IL-13, IL-17, IL-23, IL-31, TNF-α, IFN-γ, and thymic stromal lymphopoietin (TSLP) [20,109]. The gene discussed is IL31; the disease is Alzheimer disease.