In contrast to adult tumors, elevated NME1 expression correlates with aggressive neuroblastoma tumor features [23,24,25], and increased NME1 expression has been identified as a component of a 3-gene expression signature (NME1, CHD5, and PAFAH1B1) most significantly associated with poor neuroblastoma patient outcomes [26]. This evidence concerns the gene PAFAH1B1 and neoplasm.