The association of the chromosome 17q amplification with poor outcomes in neuroblastoma patients is well established and likely involves the concomitant overexpression of multiple oncogenic proteins, such as STAT proteins, BRCA1, MAP3K14/NIK, and GRB2, which are also present in this common region of amplification as illustrated in Figure 1. The gene discussed is SOAT1; the disease is neuroblastoma.