Similarly, Li et al. have confirmed that FGF2 rescues the effect of KIT inhibition and reduces the sensitivity of imatinib in GIST cells, and conversely, the antiproliferative activity of imatinib was enhanced by cotreatment with BGJ398, a potent FGFR1–3 inhibitor, alone or in the presence of added FGF2 [28]. The gene discussed is FGFR1; the disease is gastrointestinal stromal tumor.