Similarly, Li et al. have confirmed that FGF2 rescues the effect of KIT inhibition and reduces the sensitivity of imatinib in GIST cells, and conversely, the antiproliferative activity of imatinib was enhanced by cotreatment with BGJ398, a potent FGFR1–3 inhibitor, alone or in the presence of added FGF2 [28]. This evidence concerns the gene FGF2 and gastrointestinal stromal tumor.