Pazopanib, a multi-TKI targeting FGFR1, showed limited activity in heavily pretreated patients with advanced GISTs, refractory or intolerant to imatinib or sunitinib, in a multicenter phase II study, with a prolonged disease control after 17 cycles in only one patient with SDH-deficient GIST [64]. This evidence concerns the gene FGFR1 and gastrointestinal stromal tumor.