FGFR1 and gastrointestinal stromal tumor: In a phase I study, a patient with imatinib and sorafenib-refractory GIST treated with dovitinib, a multi-kinase inhibitor targeting FGFR-1, FGFR-2 and FGFR-3, had a stable disease for eight months with a metabolic response by positron emission tomography (PET) scan during therapy, and a significant symptomatic improvement [58].