Based on our previous findings that DARPin Ec1 was slowly internalized by pancreatic BxPC-3 cancer cells and that the use of non-residualizing [125I]I-PIB label provided high imaging contrast in pancreatic cancer model, we hypothesized that [125I]I-PIB-Ec1 would enable imaging of EpCAM expression in ovarian cancer. Here, EPCAM is linked to familial pancreatic carcinoma.