The analysis of the relationship between ADAMTS/TIMP-3 ratios and clinical (SJC, TJC, DAS28) and laboratory (ESR, CRP) indicators of disease activity as well as biomarkers of aggrecan turnover (CS846, AGC) in female RA patients at baseline and after 15 months of anti-TNF-α treatment are presented in Table 5. The gene discussed is ACAN; the disease is rheumatoid arthritis.