TSPOAP1 and obesity due to melanocortin 4 receptor deficiency: A further analysis of the correlations between DNA methylation of the TSPOAP1-AS1 promoter region and obesity-related markers yielded a significantly positive correlation with BMI (r = 0.1451, p = 0.0493; Figure 3A) and positive but non-significant links with waist circumference and the waist-to-hip ratio (data not shown).