SETD2 and nonpapillary renal cell carcinoma: The TCGA database showed similar expressions trend, according to Fuhrman grades, for both SETD2 and DDX11. SETD2 expression levels in normal kidney tissue were higher than those in ccRCC; in addition, those in ccRCCs decreased as the Fuhrman grades increased, while DDX11 levels were the lowest at normal kidney tissue and increased as the Fuhrman grades increased.