The TCGA database showed similar expressions trend, according to Fuhrman grades, for both SETD2 and DDX11. SETD2 expression levels in normal kidney tissue were higher than those in ccRCC; in addition, those in ccRCCs decreased as the Fuhrman grades increased, while DDX11 levels were the lowest at normal kidney tissue and increased as the Fuhrman grades increased. This evidence concerns the gene DDX11 and nonpapillary renal cell carcinoma.