This was confirmed in bladder cancer for Janus kinase (JAK) signaling pathway, where negative regulator of JAK-SOCS3 (suppressor of cytokine signaling 3) was reduced, with simultaneous upregulation of miR-221 (micro RNA), leading to enhanced cell apoptosis, and attenuated cell proliferation [40]. The gene discussed is SOCS3; the disease is urinary bladder cancer.