amara EO and V. vinifera cv Italia Hy, able to inhibit the production of hyphae and pseudo-hyphae of C. albicans strains, could prove to be successful in IBS treatment; especially considering that the same serial dilution of the two natural compounds also has the ability to linearly inhibit in a concentration-dependent manner the production of the IL-10 and TNF-α cytokines from PBMCs grown in presence of the pro-inflammatory stimulus (LPS) (Figure 2). The gene discussed is TNF; the disease is irritable bowel syndrome.