In all of the patients, age, cirrhosis status, DM, albumin, AST, ALT, platelets, AFP 12M, APRI ≥ 0.90, APRI 12M ≥ 0.53, △APRI ≥ 0, FIB-4 ≥ 2.53, FIB-4 12M ≥ 2.56, and △FIB-4 ≥ 0 showed significant associations with HCC according to univariate Cox regression analysis (Table 2). The gene discussed is GPT; the disease is hepatocellular carcinoma.