Older age (51 ± 16 years); a higher percentage of cirrhosis and HCC; lower AST, ALT, total bilirubin, INR, AFP, HBV DNA, FIB-4, and platelets 12M; and higher AST 12M, ALT 12M, AFP 12M, and FIB-4 12M were significantly associated with the subgroup with △FIB-4 ≥ 0 (Table 4). This evidence concerns the gene AFP and Cirrhosis.