AFP and hepatocellular carcinoma: In the noncirrhotic subgroup, FIB-4 12M ≥ 1.58 and △FIB-4 ≥ 0 were independent predictors of HCC, whereas in the cirrhotic subgroup, sex, DM, AFP 12M, FIB-4 12M ≥ 2.88, and △FIB-4 ≥ 0 were independent predictors of HCC.