RGS4 and glioblastoma: In the present study, we hypothesized that RGS4 overexpression in GSCs promotes GBM invasion, migration and apoptosis evasion via simultaneous expression and production of matrix metalloproteinases, and silencing of RGS4 via CRISPR plasmids knockout-RGS4 (ko-RGS4) reduced GSC invasion and migration.