This TMPRSS2-ERG positive tumour is characterised by a high PGA at 26%, pathogenic somatic SNV in TP53 (rs28934575, c.733G > A; p.Gly245Ser), as well as copy number loss of PTEN. Additional losses in MAP3K1, PIK3R1 and TP53 were observed, along with somatic alterations in the MAPK and PI3K pathways (Figure 5). Here, TP53 is linked to neoplasm.