The relevant genomic features of this TMPRSS2-ERG fusion positive case are summarized in Figure 7 and include: TP53 mutation (rs1057519999, c.716A > C; p.Asn239Thr) and SCNAs in CDK12, RAD51C, RNF43, TP53, and BRAF. This tumour presented with a high rate of SVs, including a large deletion overlapping TP53, a partial deletion of LRP1B, and an interchromosomal translocation involving CTNNA1, the downregulation of which is associated with a worse prognosis in PCa [91]. This evidence concerns the gene RNF43 and posterior cortical atrophy.