Reporting a family history of PCa, via his father, and breast cancer in his mother and sister, it was not surprising that this patient carries a pathogenic germline BRCA2 stop-gain mutation (rs80359031; c.7988A > T; p.Glu2663Val) confirmed to predispose carriers to BRCA-associated cancers. Here, BRCA2 is linked to posterior cortical atrophy.