For example, similar therapeutic strategies are proposed to applied to spinal muscular atrophy with respiratory distress type 1 (SMARD1) caused by IGHMBP2 gene mutation is a non-5q SMA, which is the second most common motor neuron disease of infancy following SMA [42]. Here, IGHMBP2 is linked to Spinal muscular atrophy with respiratory distress type 1.