In our research, we observed that deficiency of natural IgG antibodies against the CD25‐MUC1‐VEGFR1 peptide combination was strongly associated with lung cancer and that patients with early‐stage NSCLC were more likely to have low antigen‐specific IgG levels in the circulation (Table 5). The gene discussed is MUC1; the disease is non-small cell lung carcinoma.