Locally produced adipokines, especially by periadventitial adipose tissue, may affect vascular physiology and pathology.[12] It has already been described a correlation of vaspin plasma levels with carotid intima-media thickness independent of insulin resistence.[15] This indicates that vaspin may play a role in the development of atherosclerosis also in slim or non-diabetic patients. The gene discussed is SERPINA12; the disease is atherosclerosis.