To illustrate such differential behaviors, we specifically depicted genes belonging to two known pathways involved in cancer progression: the squamous differentiation, that often display somatic alterations in SQCC cancers [25], and the receptor tyrosine kinase (RTK)/RAS/RAF pathway, frequently mutated in ADC cancers [24] (Fig 4B and 4C). Here, NTRK1 is linked to AIDS dementia complex.