Thus, YopH appears to play a major role in protecting Yptb from ROS production during tissue infection, in part through its ability to block SKAP2-controlled pathways, while YopE may play a more prominent role at the phagocytic cup in inactivating Rac1 and RhoG rather than in inactivating Rac2 [67, 96–100]. Here, RAC2 is linked to infection.