Two hub genes in the pink module were identified, including Sh3kbp1 and Ubqln1. Ubqln1 is highly correlated with differentially expressed genes associated with neurodegenerative diseases, like Alzheimer’s disease, and may affect neurodevelopment [34] (Supplementary Figure 7A). The gene discussed is SH3KBP1; the disease is early-onset autosomal dominant Alzheimer disease.