PRMT5 and metastatic malignant neoplasm in the lymph nodes: The Kaplan-Meier curves also demonstrate poorer overall survival of patients with high PRMT5 expression, compared with those with low expression, with MIBC (T2-4) (P = 0.0360), absence of lymph node metastasis (P = 0.0298), and high-grade tumors (P = 0.0426; Figure 2F–2H).